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| Molecular Profile | BTK C481S |
| Therapy | Acalabrutinib |
| Indication/Tumor Type | chronic lymphocytic leukemia |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK C481S | chronic lymphocytic leukemia | predicted - resistant | Acalabrutinib | Case Reports/Case Series | Actionable | In a clinical case study, a patient with chronic lymphocytic leukemia progressed on treatment with Calquence (acalabrutinib), and was subsequently found to have acquired BTK C481S (PMID: 36287227). | 36287227 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (36287227) | Pirtobrutinib targets BTK C481S in ibrutinib-resistant CLL but second-site BTK mutations lead to resistance. | Full reference... |