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| Molecular Profile | PIK3CA E545K |
| Therapy | STX-478 |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA E545K | head and neck squamous cell carcinoma | sensitive | STX-478 | Preclinical - Pdx | Actionable | In a preclinical study, STX-478 inhibited tumor growth of a head and neck squamous cell cancer patient-derived xenograft (PDX) model harboring PIK3CA E545K (PMID: 37623743). | 37623743 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37623743) | STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts. | Full reference... |