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| Molecular Profile | FBXW7 R465H |
| Therapy | RP-6306 |
| Indication/Tumor Type | cervical cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FBXW7 R465H | cervical cancer | sensitive | RP-6306 | Preclinical - Cell culture | Actionable | In a preclinical study, a cervical cancer cell line harboring FBXW7 R465H demonstrated increased sensitivity to RP-6306 treatment compared to a cell line with wild-type FBXW7 in culture (PMID: 38032106). | 38032106 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38032106) | FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe. | Full reference... |