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Molecular Profile FBXW7 del
Therapy Ceralasertib
Indication/Tumor Type cervical cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FBXW7 del cervical cancer sensitive Ceralasertib Preclinical - Cell culture Actionable In a preclinical study, an organoid cell line generated from patient-derived xenograft tissue of cervical cancer with knockout of FBXW7 demonstrated increased sensitivity to Ceralasertib (AZD6738) treatment compared to the parental organoid cell line with wild-type FBXW7 in culture (PMID: 38032106). 38032106
PubMed Id Reference Title Details
(38032106) FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe. Full reference...