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| Molecular Profile | APC mutant |
| Therapy | JW74 |
| Indication/Tumor Type | colorectal cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| APC mutant | colorectal cancer | sensitive | JW74 | Preclinical | Actionable | In a preclinical study, JW74 reduced tumor formation and growth in a mouse model of colorectal cancer harboring an APC mutation (PMID: 21199802). | 21199802 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21199802) | Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth. | Full reference... |