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| Molecular Profile | CDKN2A negative |
| Therapy | Cetuximab + Palbociclib |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CDKN2A negative | head and neck squamous cell carcinoma | predicted - sensitive | Cetuximab + Palbociclib | Case Reports/Case Series | Actionable | In a Phase I trial, Erbitux (cetuximab) and Ibrance (palbociclib) combination therapy was safe and resulted in a disease control rate of 89% (8/9, 2 partial responses, 6 stable disease) in patients with recurrent or metastatic head and neck squamous cell carcinoma, both responders had CDKN2A-negative tumors (PMID: 27311401). | 27311401 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (27311401) | Phase I trial of palbociclib, a selective cyclin dependent kinase 4/6 inhibitor, in combination with cetuximab in patients with recurrent/metastatic head and neck squamous cell carcinoma. | Full reference... |