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Molecular Profile | BRAF V600D |
Therapy | CCT196969 |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600D | melanoma | sensitive | CCT196969 | Preclinical | Actionable | In a preclinical study, CCT196969 inhibited MEK and ERK phosphorylation and growth of melanoma cells harboring BRAF V600D in culture (PMID: 25500121, PMID: 17210691). | 25500121 17210691 |
PubMed Id | Reference Title | Details |
---|---|---|
(25500121) | Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma. | Full reference... |
(17210691) | Tumor necrosis factor-alpha blocks apoptosis in melanoma cells when BRAF signaling is inhibited. | Full reference... |