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| Molecular Profile | KMT2A rearrange |
| Therapy | Fingolimod |
| Indication/Tumor Type | acute lymphoblastic leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| KMT2A rearrange | acute lymphoblastic leukemia | sensitive | Fingolimod | Preclinical - Cell culture | Actionable | In a preclinical study, Gilenya (fingolimod) inhibited proliferation and induced cell death and cell cycle arrest in an acute lymphoblastic leukemia cell line harboring KMT2A rearrangement in culture (PMID: 37891368). | 37891368 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (37891368) | SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML. | Full reference... |