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Molecular Profile | KMT2A rearrange |
Therapy | Daunorubicin + Fingolimod |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange | acute myeloid leukemia | sensitive | Daunorubicin + Fingolimod | Preclinical - Patient cell culture | Actionable | In a preclinical study, treatment with the combination of Gilenya (fingolimod) and Cerubidine (daunorubicin) resulted in cell death in two acute myeloid leukemia cell lines harboring KMT2A rearrangements, and resulted in decreased colony formation in cells derived from a patient-derived xenograft (PDX) model in culture (PMID: 37891368) | 37891368 |
PubMed Id | Reference Title | Details |
---|---|---|
(37891368) | SET-PP2A complex as a new therapeutic target in KMT2A (MLL) rearranged AML. | Full reference... |