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Molecular Profile | BRAF V600E |
Therapy | AZD3514 + Dabrafenib |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | melanoma | sensitive | AZD3514 + Dabrafenib | Preclinical - Cell culture | Actionable | In a preclinical study, the addition of AZD3514 to Tafinlar (dabrafenib) treatment inhibited colony formation in melanoma cell lines harboring BRAF V600E in culture (PMID: 37838724). | 37838724 |
PubMed Id | Reference Title | Details |
---|---|---|
(37838724) | Androgen receptor is a determinant of melanoma targeted drug resistance. | Full reference... |