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Molecular Profile | APC Q1367* |
Therapy | G007-LK |
Indication/Tumor Type | colorectal cancer |
Response Type | resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
APC Q1367* | colorectal cancer | resistant | G007-LK | Preclinical - Patient cell culture | Actionable | In a preclinical study, a patient-derived colorectal cancer cell line harboring APC Q1367* was resistant to G007-LK treatment, as demonstrated by failure to inhibit viability in culture (PMID: 37968472). | 37968472 |
PubMed Id | Reference Title | Details |
---|---|---|
(37968472) | APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells. | Full reference... |