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Molecular Profile APC E941* APC T1459fs
Therapy G007-LK + Trametinib
Indication/Tumor Type colorectal cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC E941* APC T1459fs colorectal cancer sensitive G007-LK + Trametinib Preclinical - Cell culture Actionable In a preclinical study, the addition of G007-LK to Mekinist (trametinib) treatment resulted in increased inhibition of viability compared to Mekinist (trametinib) alone in a colorectal cancer patient-derived cell line harboring APC E941* and T1459fs in culture (PMID: 37968472). 37968472
PubMed Id Reference Title Details
(37968472) APC/PIK3CA mutations and β-catenin status predict tankyrase inhibitor sensitivity of patient-derived colorectal cancer cells. Full reference...