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Molecular Profile FGFR2 T319I PIK3CA N345K PIK3CA E453K
Therapy Inavolisib
Indication/Tumor Type Her2-receptor negative breast cancer
Response Type predicted - resistant

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 T319I PIK3CA N345K PIK3CA E453K Her2-receptor negative breast cancer predicted - resistant Inavolisib Case Reports/Case Series Actionable In a clinical case study, FGFR2 T319I was identified in circulating tumor DNA at the time of progression on Itovebi (inavolisib) in a patient with ESR1-positive, ERBB2 (HER2)-negative breast cancer harboring PIK3CA N345K and E453K (PMID: 37916958). 37916958
PubMed Id Reference Title Details
(37916958) Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations. Full reference...