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| Molecular Profile | PIK3CA H1047X |
| Therapy | Bevacizumab + Temsirolimus |
| Indication/Tumor Type | colorectal cancer |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA H1047X | colorectal cancer | predicted - resistant | Bevacizumab + Temsirolimus | Case Reports/Case Series | Actionable | In a clinical study, a colorectal cancer patient harboring a mutation at PIK3CA H1047 demonstrated progressive disease when treated with Torisel (temsirolimus) and Avastin (bevacizumab) (PMID: 21216929). | 21216929 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (21216929) | PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors. | Full reference... |