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Molecular Profile NRAS G12C
Therapy Panitumumab + Sotorasib
Indication/Tumor Type colorectal cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
NRAS G12C colorectal cancer predicted - sensitive Panitumumab + Sotorasib Case Reports/Case Series Actionable In clinical case study, treatment with the combination of Lumakras (sotorasib) and Vectibix (panitumumab) resulted in a decrease in the size of liver metastases and improved serum markers after 2 months of treatment in a patient with colorectal cancer harboring NRAS G12C (PMID: 38236605). 38236605
PubMed Id Reference Title Details
(38236605) Sotorasib is a pan-RASG12C inhibitor capable of driving clinical response in NRASG12C cancers. Full reference...