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Molecular Profile | NRAS G12C |
Therapy | Panitumumab + Sotorasib |
Indication/Tumor Type | colorectal cancer |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
NRAS G12C | colorectal cancer | predicted - sensitive | Panitumumab + Sotorasib | Case Reports/Case Series | Actionable | In clinical case study, treatment with the combination of Lumakras (sotorasib) and Vectibix (panitumumab) resulted in a decrease in the size of liver metastases and improved serum markers after 2 months of treatment in a patient with colorectal cancer harboring NRAS G12C (PMID: 38236605). | 38236605 |
PubMed Id | Reference Title | Details |
---|---|---|
(38236605) | Sotorasib is a pan-RASG12C inhibitor capable of driving clinical response in NRASG12C cancers. | Full reference... |