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Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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NRAS G12C | leukemia | predicted - sensitive | Sotorasib | Preclinical - Biochemical | Actionable | In a preclinical study, Lumakras (sotorasib) inhibited downstream signaling in leukemia cells harboring NRAS G12C in culture (PMID: 38236605). | 38236605 |
PubMed Id | Reference Title | Details |
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(38236605) | Sotorasib is a pan-RASG12C inhibitor capable of driving clinical response in NRASG12C cancers. | Full reference... |