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Molecular Profile FGFR2 G542A FGFR2 V564L FGFR2 amp
Therapy KIN-3248
Indication/Tumor Type stomach cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 G542A FGFR2 V564L FGFR2 amp stomach cancer sensitive KIN-3248 Preclinical - Pdx Actionable In a preclinical study, KIN-3248 treatment inhibited tumor growth in a gastric cancer patient derived xenograft (PDX) model harboring FGFR2 V564L and G542A with FGFR2 amplification (PMID: 38267212). 38267212
PubMed Id Reference Title Details
(38267212) Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations. Full reference...