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Molecular Profile TP53 wild-type VHL inact mut
Therapy Cabozantinib + M8891
Indication/Tumor Type renal cell carcinoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
TP53 wild-type VHL inact mut renal cell carcinoma sensitive Cabozantinib + M8891 Preclinical - Pdx Actionable In a preclinical study, M8891 and Cometriq (Cabometyx, cabozantinib) combination treatment resulted in improved tumor growth inhibition compared to monotherapies in patient-derived xenograft (PDX) models of TP53 wild-type renal cell carcinoma harboring VHL inactivating mutations (PMID: 37940144). 37940144
PubMed Id Reference Title Details
(37940144) Novel Methionine Aminopeptidase 2 Inhibitor M8891 Synergizes with VEGF Receptor Inhibitors to Inhibit Tumor Growth of Renal Cell Carcinoma Models. Full reference...