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| Molecular Profile | IDH1 R132H |
| Therapy | Panobinostat + Tazemetostat |
| Indication/Tumor Type | high grade glioma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132H | high grade glioma | sensitive | Panobinostat + Tazemetostat | Preclinical - Cell culture | Actionable | In a preclinical study, cotreatment with Tazverik (tazemetostat) sensitized mouse glioma cells expressing IDH1 R132H to Farydak (panobinostat) in culture, resulting in synergistic inhibition of cell viability (PMID: 38334611). | 38334611 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38334611) | EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor. | Full reference... |