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| Molecular Profile | HRAS G12S |
| Therapy | Alpelisib + Tipifarnib |
| Indication/Tumor Type | head and neck squamous cell carcinoma |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS G12S | head and neck squamous cell carcinoma | sensitive | Alpelisib + Tipifarnib | Preclinical - Pdx | Actionable | In a preclinical study, treatment with the combination of Piqray (alpelisib) and Zarnestra (tipifarnib) resulted in enhanced tumor growth inhibition compared to monotherapy in a patient-derived xenograft (PDX) model of head and neck squamous cell carcinoma harboring HRAS G12S (PMID: 38219706). | 38219706 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38219706) | Evolutionary dynamics of tipifarnib in HRAS mutated head and neck squamous cell carcinoma. | Full reference... |