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Molecular Profile ATM del
Therapy Radiotherapy + RP-3500
Indication/Tumor Type breast cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM del breast cancer predicted - sensitive Radiotherapy + RP-3500 Preclinical Actionable In a preclinical study, RP-3500 and radiotherapy synergistically inhibited growth of an ATM knockout mouse breast cancer cell line in culture, delayed tumor growth (p<0.001), and improved survival (20% vs 0% alive at 150 days) in a mouse syngeneic model (Cancer Res (2024) 84 (1_Supplement): A002). detail...
PubMed Id Reference Title Details
Abstract A002: Genotype-directed synthetic cytotoxicity of ATR inhibition with radiotherapy Full reference...