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| Molecular Profile | ATM del |
| Therapy | Radiotherapy + RP-3500 |
| Indication/Tumor Type | breast cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| ATM del | breast cancer | predicted - sensitive | Radiotherapy + RP-3500 | Preclinical | Actionable | In a preclinical study, RP-3500 and radiotherapy synergistically inhibited growth of an ATM knockout mouse breast cancer cell line in culture, delayed tumor growth (p<0.001), and improved survival (20% vs 0% alive at 150 days) in a mouse syngeneic model (Cancer Res (2024) 84 (1_Supplement): A002). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Abstract A002: Genotype-directed synthetic cytotoxicity of ATR inhibition with radiotherapy | Full reference... |