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Molecular Profile ATM del
Therapy Radiotherapy + RP-3500
Indication/Tumor Type colon cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATM del colon cancer predicted - sensitive Radiotherapy + RP-3500 Preclinical Actionable In a preclinical study, RP-3500 and radiotherapy synergistically inhibited growth of an ATM knockout mouse colon cancer cell line in culture and improved survival in a mouse syngeneic model, with complete responses achieved in 7 out of 8 ATM knockout mice compared to 1 out of 8 ATM wild-type mice (Cancer Res (2024) 84 (1_Supplement): A002). detail...
PubMed Id Reference Title Details
Abstract A002: Genotype-directed synthetic cytotoxicity of ATR inhibition with radiotherapy Full reference...