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Molecular Profile | PBRM1 inact mut |
Therapy | PRT1419 |
Indication/Tumor Type | clear cell renal cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
PBRM1 inact mut | clear cell renal cell carcinoma | sensitive | PRT1419 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, PRT1419 inhibited proliferation and induced apoptosis in clear cell renal cell carcinoma cells lines harboring inactivating PBRM1 mutations in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 38371625). | 38371625 |
PubMed Id | Reference Title | Details |
---|---|---|
(38371625) | PBRM1 loss is associated with increased sensitivity to MCL1 and CDK9 inhibition in clear cell renal cancer. | Full reference... |