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Molecular Profile PBRM1 loss
Therapy PRT1419 + Sunitinib
Indication/Tumor Type lung cancer
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PBRM1 loss lung cancer sensitive PRT1419 + Sunitinib Preclinical - Cell line xenograft Actionable In a preclinical study, the combination of PRT1419 and Sutent (sunitinib) inhibited tumor growth and tumor re-growth in a lung cancer cell line xenograft model with loss of PBRM1 (PMID: 38371625). 38371625
PubMed Id Reference Title Details
(38371625) PBRM1 loss is associated with increased sensitivity to MCL1 and CDK9 inhibition in clear cell renal cancer. Full reference...