Profile Response Detail

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Molecular Profile KDR Q472H
Therapy Everolimus + Vandetanib
Indication/Tumor Type epithelioid sarcoma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KDR Q472H epithelioid sarcoma predicted - sensitive Everolimus + Vandetanib Case Reports/Case Series Actionable In a Phase I trial, treatment with the combination of Afinitor (everolimus) and Caprelsa (vandetanib) was well tolerated and resulted in a median progression-free survival of 3.3 months, median overall survival of 4.6 months, clinical benefit rate of 38% in pediatric and young adult patients with advanced solid tumors, including 1 partial response in a 20 year-old patient with metastatic epithelioid sarcoma harboring germline KDR Q472H (PMID: 37879233; NCT01582191). 37879233
PubMed Id Reference Title Details
(37879233) Everolimus in combination with vandetanib in children, adolescents, and young adults: a phase I study. Full reference...