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| Molecular Profile | IDH1 R132H |
| Therapy | Panobinostat |
| Indication/Tumor Type | high grade glioma |
| Response Type | decreased response |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| IDH1 R132H | high grade glioma | decreased response | Panobinostat | Preclinical - Cell culture | Actionable | In a preclinical study, mouse glioma cells expressing IDH1 R132H were less sensitive to Farydak (panobinostat) compared to IDH1 wild-type cells in culture (PMID: 38334611). | 38334611 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38334611) | EZH2 Inhibition Sensitizes IDH1R132H-Mutant Gliomas to Histone Deacetylase Inhibitor. | Full reference... |