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| Molecular Profile | PBRM1 inact mut |
| Therapy | PRT2527 |
| Indication/Tumor Type | clear cell renal cell carcinoma |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PBRM1 inact mut | clear cell renal cell carcinoma | predicted - sensitive | PRT2527 | Preclinical - Cell culture | Actionable | In a preclinical study, PRT2527 inhibited spheroid growth in clear cell renal cell carcinoma cell lines harboring inactivating PBRM1 mutations in culture (PMID: 38371625). | 38371625 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38371625) | PBRM1 loss is associated with increased sensitivity to MCL1 and CDK9 inhibition in clear cell renal cancer. | Full reference... |