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| Molecular Profile | HRAS Q61H |
| Therapy | BTX-6654 |
| Indication/Tumor Type | uterine cancer |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| HRAS Q61H | uterine cancer | sensitive | BTX-6654 | Preclinical - Cell culture | Actionable | In a preclinical study, BTX-6654 inhibited proliferation of a uterine cancer cell line harboring HRAS Q61H in 3D culture (PMID: 38224565). | 38224565 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38224565) | Cereblon-based Bifunctional Degrader of SOS1, BTX-6654, Targets Multiple KRAS Mutations and Inhibits Tumor Growth. | Full reference... |