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Molecular Profile | CDKN2A R80* |
Therapy | Palbociclib |
Indication/Tumor Type | stomach carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CDKN2A R80* | stomach carcinoma | sensitive | Palbociclib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, a gastric carcinoma cell line harboring CDKN2A R80* was sensitive to Ibrance (palbociclib) both in culture and in cell line xenograft models (PMID: 26380006, PMID: 20952405). | 26380006 20952405 |
PubMed Id | Reference Title | Details |
---|---|---|
(26380006) | CDK4/6 inhibitor suppresses gastric cancer with CDKN2A mutation. | Full reference... |
(20952405) | COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. | Full reference... |