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Molecular Profile CDK12 inact mut
Therapy unspecified PARP inhibitor
Indication/Tumor Type prostate cancer
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CDK12 inact mut prostate cancer predicted - sensitive unspecified PARP inhibitor Clinical Study - Meta-analysis Actionable In a combined analysis of 6 clinical trials, PARP inhibitor therapy improved radiographic progression-free survival (17 vs 14 mo, HR 0.5) and overall survival (36 vs 27 mo, HR 0.63) compared to placebo when combined with AR pathway inhibitors in patients with metastatic castration-resistant prostate cancer harboring CDK12 mutations, and resulted in an objective response rate of 5% (2/44) as monotherapy (PMID: 38484203; NCT02987543, NCT03732820, NCT03395197, NCT03748641, NCT02952534, NCT03148795). 38484203
PubMed Id Reference Title Details
(38484203) Efficacy of Poly(ADP-ribose) Polymerase Inhibitors by Individual Genes in Homologous Recombination Repair Gene-Mutated Metastatic Castration-Resistant Prostate Cancer: A US Food and Drug Administration Pooled Analysis. Full reference...