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Molecular Profile | ALK I1170N |
Therapy | Lorlatinib |
Indication/Tumor Type | neuroblastoma |
Response Type | predicted - sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ALK I1170N | neuroblastoma | predicted - sensitive | Lorlatinib | Case Reports/Case Series | Actionable | In a retrospective analysis, Lorbrena (lorlatinib) treatment resulted in complete remission in a neuroblastoma patient harboring ALK I1170N (PMID: 38787533; NCT04477681). | 38787533 |
PubMed Id | Reference Title | Details |
---|---|---|
(38787533) | Sequential analysis of cfDNA reveals clonal evolution in neuroblastoma patients receiving ALK targeted therapy. | Full reference... |