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Molecular Profile | KIT D816V |
Therapy | Nilotinib |
Indication/Tumor Type | Advanced Solid Tumor |
Response Type | decreased response |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT D816V | Advanced Solid Tumor | decreased response | Nilotinib | Preclinical | Actionable | In a preclinical study, Tasigna (nilotinib) decreased viability of cells expressing KIT D816V in culture, but did not inhibit KIT phosphorylation or growth of KIT D816V-expressing tumors in mouse models (PMID: 20442311). | 20442311 |
PubMed Id | Reference Title | Details |
---|---|---|
(20442311) | Preclinical evaluation of nilotinib efficacy in an imatinib-resistant KIT-driven tumor model. | Full reference... |