Profile Response Detail

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Molecular Profile KIT D816V
Therapy Nilotinib
Indication/Tumor Type Advanced Solid Tumor
Response Type decreased response

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
KIT D816V Advanced Solid Tumor decreased response Nilotinib Preclinical Actionable In a preclinical study, Tasigna (nilotinib) decreased viability of cells expressing KIT D816V in culture, but did not inhibit KIT phosphorylation or growth of KIT D816V-expressing tumors in mouse models (PMID: 20442311). 20442311
PubMed Id Reference Title Details
(20442311) Preclinical evaluation of nilotinib efficacy in an imatinib-resistant KIT-driven tumor model. Full reference...