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Molecular Profile | CSF3R W341C CSF3R W791* |
Therapy | Ruxolitinib |
Indication/Tumor Type | hematologic cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
CSF3R W341C CSF3R W791* | hematologic cancer | sensitive | Ruxolitinib | Preclinical - Cell culture | Actionable | In a preclinical study, (ruxolitinib) inhibited viability of a cell line expressing CSF3R W341C and W791* in culture (PMID: 28652245). | 28652245 |
PubMed Id | Reference Title | Details |
---|---|---|
(28652245) | Unpaired Extracellular Cysteine Mutations of CSF3R Mediate Gain or Loss of Function. | Full reference... |