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| Molecular Profile | CD274 positive |
| Therapy | MCLA-145 + Pembrolizumab |
| Indication/Tumor Type | Advanced Solid Tumor |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | Advanced Solid Tumor | predicted - sensitive | MCLA-145 + Pembrolizumab | Phase I | Actionable | In a Phase I trial, treatment with the combination of MCLA-145 and Keytruda (pembrolizumab) demonstrated safety and activity in patients with CD274 (PD-L1)-positive advanced solid tumors (n=19), resulting in 1 complete response in a patient with non-small cell lung cancer and 1 partial response in a patient with Merkel cell carcinoma, and a disease control rate of 68% (J Clin Oncol 42, 2024 (suppl 16; abstr 2520); NCT03922204). | detail... |
| PubMed Id | Reference Title | Details |
|---|---|---|
| Phase I study of MCLA-145, a bispecific antibody targeting CD137 and PD-L1, in solid tumors, as monotherapy or in combination with pembrolizumab. | Full reference... |