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Molecular Profile | KIT V560G KIT D816V |
Therapy | Ponatinib |
Indication/Tumor Type | mast-cell leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KIT V560G KIT D816V | mast-cell leukemia | sensitive | Ponatinib | Preclinical | Actionable | In a preclinical study, Iclusig (ponatinib) inhibited growth of a human mast cell line harboring both KIT V560G and KIT D816V in culture (PMID: 24552773). | 24552773 |
PubMed Id | Reference Title | Details |
---|---|---|
(24552773) | Ponatinib induces apoptosis in imatinib-resistant human mast cells by dephosphorylating mutant D816V KIT and silencing β-catenin signaling. | Full reference... |