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| Molecular Profile | PIK3CA act mut |
| Therapy | Alpelisib |
| Indication/Tumor Type | female reproductive organ cancer |
| Response Type | predicted - sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| PIK3CA act mut | female reproductive organ cancer | predicted - sensitive | Alpelisib | Clinical Study | Actionable | In a clinical study, Piqray (alpelisib) treatment was well tolerated and demonstrated activity in patients with advanced gynecologic cancers harboring activating mutations in PIK3CA, resulting in an overall response rate of 28% (10/36, all partial responses), a disease control rate of 61% (22/36), including stable disease in 12 patients, a median duration of response of 13 months, and a median progression-free survival of 6.3 months (PMID: 38518529; NCT04085653). | 38518529 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (38518529) | Alpelisib for PIK3CA-mutated advanced gynecological cancers: First clues of clinical activity. | Full reference... |