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| Molecular Profile | NRAS G12D |
| Therapy | Alpelisib + Binimetinib |
| Indication/Tumor Type | acute myeloid leukemia |
| Response Type | sensitive |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| NRAS G12D | acute myeloid leukemia | sensitive | Alpelisib + Binimetinib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Mektovi (binimetinib) and Alpelisib (BYL719) inhibited proliferation in a human acute myeloid leukemia (AML) cell line harboring NRAS G12D in culture, and decreased disease burden in xenograft models (PMID: 24569456). | 24569456 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (24569456) | Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α. | Full reference... |