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Molecular Profile | BRAF V600E |
Therapy | Vemurafenib |
Indication/Tumor Type | hairy cell leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF V600E | hairy cell leukemia | sensitive | Vemurafenib | Case Reports/Case Series | Actionable | In a clinical case study, Zelboraf (vemurafenib) treatment resulted in complete resolution of the brain lesions after 3 months of treatment, decreased spleen size, and resolution of leukemic retinopathy in a patient with hairy cell leukemia harboring BRAF V600E (PMID: 36713531). | 36713531 |
BRAF V600E | hairy cell leukemia | sensitive | Vemurafenib | Phase II | Actionable | In two Phase II clinical studies, patients with refractory hairy cell leukemia harboring BRAF V600E responded to Zelboraf (vemurafenib) with overall response rates of 96% (25/26) and 100% (24/24) as well as complete response rates of 35% (9/26) and 42% (10/24) with median follow up times of 8 and 12 weeks, respectively (PMID: 26352686). | 26352686 |
PubMed Id | Reference Title | Details |
---|---|---|
(26352686) | Targeting Mutant BRAF in Relapsed or Refractory Hairy-Cell Leukemia. | Full reference... |
(36713531) | Case report: A case of classic hairy cell leukemia with CNS involvement treated with vemurafenib. | Full reference... |