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Molecular Profile | BRAF K601E |
Therapy | PF-07799933 |
Indication/Tumor Type | melanoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF K601E | melanoma | sensitive | PF-07799933 | Preclinical - Pdx | Actionable | In a preclinical study, PF-07799933 treatment resulted in tumor regression in a patient-derived xenograft (PDX) model of melanoma harboring BRAF K601E (PMID: 38691346). | 38691346 |
PubMed Id | Reference Title | Details |
---|---|---|
(38691346) | A next-generation BRAF inhibitor overcomes resistance to BRAF inhibition in patients with BRAF-mutant cancers using pharmacokinetics-informed dose escalation. | Full reference... |