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Molecular Profile BRAF V600E
Therapy Binimetinib + Encorafenib
Indication/Tumor Type malignant fibrous histiocytoma
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF V600E malignant fibrous histiocytoma sensitive Binimetinib + Encorafenib Case Reports/Case Series Actionable In a clinical case study, treatment with the combination of Mektovi (binimetinib) and Braftovi (encorafenib) resulted in a clinical response after two months in a patient with angiomatoid fibrous histiocytoma harboring BRAF V600E, along with EWSR1-CREB1 (e7:e7), and in a preclinical study, combination treatment with Mektovi (binimetinib) and Braftovi (encorafenib) inhibited viability of cells in culture (PMID: 38885476). 38885476
PubMed Id Reference Title Details
(38885476) Modeling Extraordinary Response Through Targeting Secondary Alterations in Fusion-Associated Sarcoma. Full reference...