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Molecular Profile | ARID1A G1450fs |
Therapy | Tulmimetostat |
Indication/Tumor Type | urinary bladder cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A G1450fs | urinary bladder cancer | sensitive | Tulmimetostat | Preclinical - Cell culture | Actionable | In a preclinical study, Tulmimetostat inhibited viability in 5/6 bladder cancer cell lines harboring ARID1A loss of function mutations including ARID1A G1450fs in culture (PMID: 38833522). | 38833522 |
PubMed Id | Reference Title | Details |
---|---|---|
(38833522) | Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers. | Full reference... |