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Molecular Profile | ARID1A P549fs ARID1A N756fs |
Therapy | Tulmimetostat |
Indication/Tumor Type | ovarian clear cell carcinoma |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A P549fs ARID1A N756fs | ovarian clear cell carcinoma | sensitive | Tulmimetostat | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Tulmimetostat inhibited viability of an ovarian clear cell carcinoma cell line harboring ARID1A N756fs and P549fs in culture and inhibited tumor growth in a cell line xenograft model (PMID: 38833522). | 38833522 |
PubMed Id | Reference Title | Details |
---|---|---|
(38833522) | Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers. | Full reference... |