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Molecular Profile FGFR2 amp
Therapy Infigratinib + Trametinib
Indication/Tumor Type Cancer of Unknown Primary
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 amp Cancer of Unknown Primary sensitive Infigratinib + Trametinib Preclinical - Pdx & cell culture Actionable In a preclinical study, the combination of Truseltiq (infigratinib) and Mekinist (trametinib) inhibited Akt and Mapk signaling, induced apoptosis, and synergistically decreased proliferation in FGFR2-amplified cell lines derived from patients with cancer of unknown primary in culture and decreased tumor volume in patient-derived xenograft (PDX) models (PMID: 39033323). 39033323
PubMed Id Reference Title Details
(39033323) Synergic activity of FGFR2 and MEK inhibitors in the treatment of FGFR2-amplified cancers of unknown primary. Full reference...