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Molecular Profile | BRAF del exon2-10 BRAF V600E |
Therapy | Vemurafenib |
Indication/Tumor Type | melanoma |
Response Type | predicted - resistant |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
BRAF del exon2-10 BRAF V600E | melanoma | predicted - resistant | Vemurafenib | Case Reports/Case Series | Actionable | In a clinical case study, a deletion of BRAF exons 2-10 was identified in the post-progression biopsy of three melanoma patients harboring BRAF V600E who were treated with Zelboraf (vemurafenib) (PMID: 22113612). | 22113612 |
PubMed Id | Reference Title | Details |
---|---|---|
(22113612) | RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). | Full reference... |