Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Molecular Profile | BTK A428D |
| Therapy | BGB-16673 |
| Indication/Tumor Type | chronic lymphocytic leukemia |
| Response Type | predicted - resistant |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK A428D | chronic lymphocytic leukemia | predicted - resistant | BGB-16673 | Case Reports/Case Series | Actionable | In a clinical case study, a patient with chronic lymphocytic leukemia harboring BTK T474I experienced progressive disease after an initial response on treatment with BGB-16673 and was found to have acquired BTK A428D and lost BTK T474I (PMID: 39048721). | 39048721 |
| PubMed Id | Reference Title | Details |
|---|---|---|
| (39048721) | Mutation in Bruton Tyrosine Kinase (BTK) A428D confers resistance To BTK-degrader therapy in chronic lymphocytic leukemia. | Full reference... |