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Molecular Profile FLT3 exon 14 ins
Therapy Gilteritinib + Metformin
Indication/Tumor Type acute myeloid leukemia
Response Type sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins acute myeloid leukemia sensitive Gilteritinib + Metformin Preclinical - Cell line xenograft Actionable In a preclinical study, the combination of Xospata (gilteritinib) and Glucophage (metformin) synergistically inhibited viability and induced apoptosis and cell cycle arrest in acute myeloid leukemia cell lines and patient-derived cells harboring a FLT3-ITD mutation in culture, and reduced leukemia burden and increased median survival compared to either drug alone (>70 days vs 46 days (metformin) or 52 days (gilteritinib)) in cell line xenograft models (PMID: 39019012). 39019012
PubMed Id Reference Title Details
(39019012) Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling. Full reference...