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Molecular Profile | FLT3 exon 14 ins |
Therapy | Gilteritinib + Metformin |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Gilteritinib + Metformin | Preclinical - Cell line xenograft | Actionable | In a preclinical study, the combination of Xospata (gilteritinib) and Glucophage (metformin) synergistically inhibited viability and induced apoptosis and cell cycle arrest in acute myeloid leukemia cell lines and patient-derived cells harboring a FLT3-ITD mutation in culture, and reduced leukemia burden and increased median survival compared to either drug alone (>70 days vs 46 days (metformin) or 52 days (gilteritinib)) in cell line xenograft models (PMID: 39019012). | 39019012 |
PubMed Id | Reference Title | Details |
---|---|---|
(39019012) | Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling. | Full reference... |