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Molecular Profile IDH1 act mut
Therapy Ivosidenib
Indication/Tumor Type low grade glioma
Response Type predicted - sensitive

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 act mut low grade glioma predicted - sensitive Ivosidenib Clinical Study Actionable In a retrospective analysis, Tibsovo (ivosidenib) treatment was well tolerated in patients with glioma harboring an IDH1 mutation, and resulted in a partial response in 13.6% (3/22), minor response in 22.7% (5/22), and stable disease in 54.5% (12/22) of patients with nonenhancing disease, and stable disease in 62.5% (5/8) of patients with enhancing disease (PMID: 38496920). 38496920
PubMed Id Reference Title Details
(38496920) Use, access, and initial outcomes of off-label ivosidenib in patients with IDH1 mutant glioma. Full reference...