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Molecular Profile | ARID1A del |
Therapy | Capivasertib |
Indication/Tumor Type | stomach cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A del | stomach cancer | sensitive | Capivasertib | Preclinical - Cell line xenograft | Actionable | In a preclinical study, Truqap (capivasertib) inhibited proliferation and colony formation in an ARID1A knockout gastric cancer cell line in culture, and inhibited tumor growth in a cell line xenograft model (PMID: 39003371). | 39003371 |
PubMed Id | Reference Title | Details |
---|---|---|
(39003371) | The AKT inhibitor AZD5363 elicits synthetic lethality in ARID1A-deficient gastric cancer cells via induction of pyroptosis. | Full reference... |