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Molecular Profile | ARID1A inact mut |
Therapy | Tulmimetostat |
Indication/Tumor Type | endometrial cancer |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
ARID1A inact mut | endometrial cancer | sensitive | Tulmimetostat | Preclinical - Pdx | Actionable | In a preclinical study, Tulmimetostat inhibited tumor growth in endometrial cancer patient-derived xenograft (PDX) models harboring loss of function mutations in ARID1A (PMID: 38833522). | 38833522 |
PubMed Id | Reference Title | Details |
---|---|---|
(38833522) | Comprehensive Target Engagement by the EZH2 Inhibitor Tulmimetostat Allows for Targeting of ARID1A Mutant Cancers. | Full reference... |