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Molecular Profile | KMT2A rearrange |
Therapy | Birabresib + FHD-286 |
Indication/Tumor Type | acute myeloid leukemia |
Response Type | sensitive |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
KMT2A rearrange | acute myeloid leukemia | sensitive | Birabresib + FHD-286 | Preclinical - Patient cell culture | Actionable | In a preclinical study, the combination of FHD-286 and Birabresib (OTX015) synergistically inhibited viability of acute myeloid leukemia cell lines and a patient-derived cell line harboring a KMT2A rearrangement in culture (PMID: 38437498). | 38437498 |
PubMed Id | Reference Title | Details |
---|---|---|
(38437498) | BRG1/BRM inhibitor targets AML stem cells and exerts superior preclinical efficacy combined with BET or Menin inhibitor. | Full reference... |